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Preparation and subsequent optimisation yielded a range of potent and highly selective SSRIs.
These analyses and the subsequent optimisation of the ligands are challenging owing to the narrow affinity range of the inhibitors and the shallow binding sites.
Subsequent optimisation revealed that replacement of MEA by AMP can reduce the energy requirements of CO2-capture units by 20% and the solvent consumption by 15%.
Subsequent optimisation resulted in identification of 19, which has high affinity for the dopamine D3 receptor (pKi 8.3) and ≥100-fold selectivity over other aminergic receptors.
Quantification of physical properties of fossil fuel fired flames is becoming increasingly important to achieve in-depth understanding and subsequent optimisation of combustion processes.
As a result a novel series of oxadiazole CGRP receptor antagonists has been identified and the subsequent optimisation to enhance both potency and bioavailability is presented.
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The calculation of these polyhedrons, however, raised the redundancy issue amongst process variables, affecting the efficiency of the subsequent optimisations.
Our practice includes comprehensive assessment to identify comorbidities, allowing subsequent medical optimisation prior to aneurysm repair.
Subsequent lead optimisation led to the discovery of penta-substituted benzimidazoles that exhibit attractive in vitro and in vivo calcium-sensing receptor (CaSR) inhibitory profiles.
Monitoring of cardiac output (with subsequent haemodynamic optimisation) may improve outcome after high-risk surgery.
Subsequent parametric and optimisation studies, which were performed for many practical geometries using the developed model, reveal that, whilst VS sandwich panels show a significant improvement in global buckling performance, they suffer a reduction in shear crimping performance when compared to their straight-fibre counterparts.
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