These values were compared with each subsequent on-study ACR measures that were monitored yearly.
Similarly, denosumab reduced the risk of first and subsequent on-study SSE by 22% versus zoledronic acid (rate ratio, 0.78; 95% CI 0.65 0.92; P = 0.004; Figure 1B).
In a comparison of SSE and SRE as end points, there were 296 fewer first on-study SSEs than first on-study SREs (641 versus 937, respectively), and there were 340 fewer first and subsequent on-study SSEs than first and subsequent on-study SREs (738 versus 1078; Table 1).
Among the patients with first and subsequent on-study SSEs, the numbers of patients in the zoledronic acid and denosumab arms with each event type were similar except for radiation to bone, which was less frequent in the denosumab arm than in the zoledronic acid arm (272 versus 341); similar results were observed for patients with first and subsequent on-study SREs.
First and subsequent on-study SSEs occurred in fewer patients in the denosumab arm (n = 329; 0.35 mean events per patient) versus the zoledronic acid arm (n = 409; 0.43 mean events per patient; Table 2); similar results were observed for patients with first and subsequent on-study SREs.
As anticipated, first on-study pathologic fractures were less numerous when defined as SSE than when defined as SRE (36 versus 328), as were first and subsequent on-study fractures (32 versus 391).
Here as elsewhere laboratory studies will have to be followed by clinical trials and subsequent follow-on studies, which will determine how applicable cellular therapeutics may be.
Enrollment of subsequent patients on study was restricted to patients with normal baseline total serum bilirubin levels, and no further DLT was observed until the irinotecan dose was escalated to 130 mg m−2.
Subsequent studies on one particular Tas model phenotype, B6 T Orl/+ XYAKR, suggested severely reduced Sry expression as a possible cause of sex reversal (24).
Based on results from previous subsequent memory studies on one-shot learning [30], [31], [32], we hypothesized that stronger midfusiform activation during learning (across repetitions) would be associated with better long-term memory both within and across individuals.
We recorded animal weights prior to surgery, after surgery, and on subsequent study days.
