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The probability that subsequent mutations could reshape the unfolded protein into a form with a new function is essentially zero, and that is an evolutionary cul de sac.
Subclones arise due to subsequent mutations that diversify the population.
The mutations characterizing the two types of clones thus presumably conferred the long-term evolvability by affecting subsequent mutations.
Such cells then carry the risk that subsequent mutations may lead to neoplastic evolution of individual clones.
These subsequent mutations are restricted to subpopulations of cells where they contribute to clonal fitness and thus influence resistance to treatment and patient survival.
The most appealing thing about Carr's horror is the number of forms it takes, and the subsequent mutations the story's landscape carries out along the way.
The importance of this neutral variation is its effect on the fitness of subsequent mutations.
Subsequent mutations then facilitate progression to serous tubal intraepithelial carcinoma and ultimately to serous carcinoma.
For example, the order with which mutations arise in independent microcosms can potentially affect the fixation of subsequent mutations [50].
It is hypothesized that through gene duplications and subsequent mutations, common ancestor proteins gave rise to families of homologous proteins [17].
One hypothesis is that subsequent mutations in the HA or NA proteins was sufficient to facilitate human-to-human transmission of S-OIV.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com