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In the past 2 years, novel technologies such as zinc finger nucleases, Transcription Activator-Like Effector (TALE) nucleases or Clustered Regularly Interspaced Short Palindromic Repeats (CRIPSR /Cas9 have shown promise for generating double-strand breaks and subsequent lesions in genomes of higher organisms (Gaj et al. 2013).
Damaged ECs were the primary cause of subsequent lesions.
As previously reported, damage to ECs initiated subsequent lesions within irradiated intestines, such as inflammation.
An alternative explanation involves a deficiency in blood supply, and subsequent lesions of the anterior horn cells following compression [ 21].
Treatment of colon cancer mainly implicates direct or indirect DNA-damaging agents and increased repair or tolerances towards subsequent lesions contribute to generate resistant populations.
All clonal pairs displayed concordant ER-positivity between paired lesions, yet the subsequent lesions were not restricted to low-grade disease.
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An effective virus-like particle (VLP) based prophylactic vaccine designed to protect against persistent infection with human papillomavirus (HPV) types 16 and 18 and subsequent lesion development will need to induce a strong humoral and cellular immune response capable of providing long-term protection.
Transient particle-hemodynamic simulations were conducted in a model of the rabbit aorto-celiac junction to investigate mechanisms responsible for localized monocyte attachment and subsequent lesion formation.
Due to obligate surgical excision of newly diagnosed cancers, subsequent lesion progression cannot be followed.
Vertebral bodies are highlighted on the CT image and restrict the search space for subsequent lesion detection.
The absence of an association between functional and morphological assessments of the vasculature may be due to a time lag between endothelial dysfunction and subsequent lesion development.
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