Orthotopic or ectotopic implantation of cancer cells in the skin or mammary fat pad, with the formation of primary tumors and the subsequent formation of metastasis, in part resembles the multiple stages involved in malignant breast cancer development in patients [ 16].
Therefore, rapid vacuole formation and the subsequent formation of 'trench' in the vacuoles guaranteed the restriction of GzmB in the vacuoles, leading to the reuptake of degranulated GzmB by the killer cells themselves.
To exclude the possibility that changes in the barrier function resulted from cell death and the subsequent formation of holes in the monolayer, we tested the cytotoxic effects of 100 nM Tat on D407 cells.
There are two genetic variants of Glo1 differing at position 111 with a glutamate-alanine substitution (E111A) resulting in subsequent formation of three Glo1 isozymes in heterozygotes.
The micromodel tests indicate that the penetration of the alkaline solution into the crude oil and the subsequent formation of a water-in-oil (W/O) emulsion reduce the mobility of the water phase and divert the injected water into the unswept region, thereby improving the sweep efficiency.
This contrasts with the strong correlations between reducing sugars and subsequent formation of acrylamide in potatoes.
To sum up, the described characteristic vibration bands are responsible for creating the appropriate intermolecular interactions with the polymer particles (PPy, PTh, or PMeTh) of absorbent material pattern and thus the subsequent formation of fingerprints in the polymer matrix.
The increased amount of lead bound to the ALAD 2 isozyme should result in decreased lead available to inhibit ferrochelatase, which would thus be available to catalyze the formation of heme with subsequent formation of hemoglobin in the presence of Fe2+.
TNF-α is a cytokine known to diffuse and upregulate inducible nitric oxide synthase in adjacent cells, resulting in the generation of NO and the subsequent formation of peroxynitrite (ONOO−) in the mitochondria which leads to mitochondrial oxidative stress.
Even though few studies have shown presence in human urothelium, nNOS and the subsequent formation of nitric oxide in afferent nerve terminals seem to play an important role for normal bladder function as disruption of its gene causes voiding abnormalities in mice [ 110, 124].
