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We allowed at least 30 min washout before application of subsequent drugs.
It is also conceivable that certain drugs could be used only to induce specific resistant forms of the disease, which could be treated effectively by subsequent drugs [ 115].
They optimized relative timing and sequence of drug addition; over time, the first drug 'rewires' the signaling network, by moving cells within state-space, maximizing responses to subsequent drugs.
The clinical superiority of ranibizumab over both observation and photodynamic therapy was well documented in both the MARINA 4 (7.2 letters vs −10.4 letters) and ANCHOR 5 (11.3 letters vs −9.5 letters) studies, thus establishing ranibizumab as the standard against which all subsequent drugs are compared.
If this finding is replicated for other new drugs, it may be indicative that by encouraging use of drugs deemed not cost-effective by NICE, the CDF may be impacting on early adoption of subsequent drugs that are more cost-effective.
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These pivotal findings set the stage for subsequent drug development.
Initial studies were designed to determine the optimal testing conditions for subsequent drug studies.
If a subsequent drug test shows levels that are abnormal, that could lead to further testing or questioning, Bowers said.
During a subsequent drug-free CPP test, rats spent an equivalent amount of time within the conditioning chambers (Figure 4b).
Crystal structure of FTO95 and ALKBH596 was determined, which would facilitate the understanding of substrate recognition and subsequent drug development.
They exhibited enhanced mechanical strength, preventing pore collapse and favoring the subsequent drug release.
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