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Subsequent dosage adjustments were allowed while maintaining the blind.
A potential approach would be to provide full dosages for the first 24 to 48 hours with subsequent dosage reduction based on clinical response [25].
Aminoglycoside dosing is based on weight and kidney function, with subsequent dosage modifications guided by therapeutic drug monitoring.
Subsequent dosage adjustments were advised if anti-Xa levels fell outside this range; see Figure 1 for the algorithm.
A potential approach would be to provide full dosages for the first 24 to 48 hours with subsequent dosage reduction based on clinical response [ 25].
Calculation of the AUC for an individual patient and subsequent dosage adjustment using dosing software should be considered the ideal approach.
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Like in the present study, early-phase small intestinal permeability changes were induced by administering two subsequent dosages of the NSAID indomethacin (75 and 50 mg).
As a model of early-stage small intestinal enteropathy, a number of experiments was performed; in each experiment, two subsequent dosages of the NSAID indomethacin (75 and 50 mg) were administered to fasting healthy human subjects.
Finally, a recent study (Add-on Lantus to Oral Hypoglycemic Agents [ALOHA] study) demonstrated that initiation of insulin glargine to achieve treatment target in Japanese type 2 diabetic patients (n = 3,180) on a basal-supported oral therapy (BOT) regimen is possible under real-life conditions using an appropriate starting dosage and subsequent dose adjustment (62).
Subsequent dose escalation to the original dosage was allowed providing the patient tolerated the doses given at the 75% level.
Filtered genes identified to be differentially expressed by haploid/diploid signals lower than 0.3 with a P-value not higher than 0.05 were considered for subsequent gene dosage measurements.
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