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Our findings provide evidence that platelet-derived CXCL12 is an important chemokine through which differential involvement of CXCR4 and CXCR7 regulates monocyte functions, survival, and subsequent differentiation.
Monocyte infiltration and subsequent differentiation into macrophages has been shown to be crucial during inflammation.
Subsequent differentiation resulted in generation of mature 3D networks of neurons (MAP2+) and glia (S100beta+) cells.
Subsequent differentiation to glial-like cells was confirmed by the expression of S100.
The complex process of monocyte recruitment and their subsequent differentiation into various macrophage subpopulations is depicted in Figure 1.
Biomaterials provide a framework for cell attachment, ECM deposition and subsequent differentiation into a designated lineage (Lutolf et al., 2009).
The results demonstrated that collagen/Matrigel scaffolds supported EBs formation and their subsequent differentiation in a single three dimensional environment.
Subsequent differentiation of these mixed cultures would fail to generate single pure lineages needed for transplantation, modeling or population based gene expression studies (e.g. RNA-seq).
Insight into the accretion of the Earth and its subsequent differentiation can be gained through knowledge of the present-day Earth composition.
Preexposure to stimulus X retarded subsequent differentiation of responding to reinforced A trials and non-reinforced AX trials, suggesting that CS-preexposure retarded development of inhibitory conditioning.
Previous work has produced approaches of varying yield and complexity but does not permit frozen storage of cells for subsequent differentiation in culture.
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