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This study was conducted to investigate whether the dose of estradiol (E) administered acutely, or chronic delivery of one dose of E impacts acquisition and subsequent cocaine self-administration in ovariectomized (OVX) female rats.
Subsequent cocaine daily 3-hr sessions continued until stable responding (> 20 infusions, < 20% variability in number of infusions across three daily sessions, > 70% discriminative responding in "active" portal vs "inactive" portal) was achieved in both groups.
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In addition, we tested whether habituation to the unheated hot-plate apparatus, that "normalizes" the basal hypoalgesic phenotype of SHR, alters the subsequent cocaine-induced analgesia (CIA) in this strain.
In order to evaluate the contribution of cognitive/emotional processes in the analgesic effect of cocaine, another objective of our study was to evaluate whether habituation to the unheated hot-plate apparatus, that "normalizes" the basal nociception of SHR, alters the subsequent cocaine-induced analgesia (CIA) in this strain.
In addition, the original CPP displayed by R and NR mice subsequent to cocaine conditioning was similar and no correlation was found between the strength of this CPP and the extent of reinstatement after extinction.
However, a similar anisomycin dosing regimen failed to affect subsequent expression of cocaine-CPP when additional cocaine conditioning trial was used in the absence of additional saline trial.
Womack turned again to cocaine, and his subsequent albums suffered.
The current review highlights the utility of positron emission tomography (PET) imaging to study the neurobiological substrates underlying vulnerability to cocaine addiction and subsequent adaptations following chronic cocaine self-administration in nonhuman primate models of cocaine abuse.
This is despite displaying robust original CPP to cocaine, and a subsequent successful extinction of this CPP.
When the role of E2 in 'binge' cocaine intake and subsequent motivational changes is examined, E2 treatment increases the initial binge length and enhances cocaine self-administration [ 95].
Relapse use of cocaine and the subsequent withdrawal can trigger depression-like symptoms with activated confusion that may be mistaken for dementia.
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