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The major part of the subsequent attenuated expedition was a three-month cruise to the eastern Antarctic, under the leadership of second-in-command Frank Wild.
The subsequent attenuated T strain, T_att, was used as a vaccine in Australia between 1991 and 1993 [ 15].
Furthermore, Smad4 knockdown yielded in Smad3 hyperactivation, likely due to reduced nuclear shuttling with subsequent attenuated dephosphorylation and degradation of phospho-Smads.
Nevertheless, Oct4 and Sox2 acetylation led to impaired Oct4/Sox2 heterodimer formation (Fig. 2C) and subsequent attenuated transcriptional activity 46, 47.
In addition, increased concentrations of the extracellular domain of Flt-1 trap and sequester VEGF in the extracellular matrix [ 188, 189], resulting in less available VEGF and subsequent attenuated VEGF/KDR signalling.
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Consequently, a lower specificity for the latter and a subsequent attenuating of the effect measures may account for the failure to detect an association.
This suggests that, over time, the association between baseline weight z score and subsequent measurements attenuates while that of psychostimulants becomes more prominent.
Pretreatment of ARVM with the non-selective PDE inhibitor isobutylmethylxanthine (IBMX) attenuated subsequent PKD activation by ET1.
First, siRNA-mediated JNK knockdown in primary cultures attenuated subsequent PIAS1 modification in response to H2O2 treatment (Fig. 1 C).
In contrast to other TRPA1 agonists, parthenolide can desensitize the channel, leading to a decrease in neuropeptide release from TRPA1-containing nerve endings, and pretreatment of rats with parthenolide attenuated subsequent headache-like responses to dural application of mustard oil, indicating functional desensitization of the channel.
Warwick et al. [ 26] in a study evaluating the time-dependent effects on breast cancer survival, suggested that tumor grade, lymph-nodal status, and tumor size at the time of diagnosis have a lasting influence on subsequent survival, albeit attenuated in later years.
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