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Low activity of an enzyme may result in the subsequent accumulation of the enzyme's substrate, which may be toxic at high levels.
The problem is resolved if, as hypothesized, nucleation results from a number of simultaneous alpha to beta transitions, while subsequent accumulation results from individual events.
Subsequent accumulation of reactive oxygen (ROS) and nitrogen (RNS) species enhances the enzymatic degradation of the extracellular matrix (ECM).
Selenium (Se) mobilization in the soils of the Pariette Draw and subsequent accumulation into the Pariette Wetlands threaten wildlife.
It blocks the enzymatic conversion of 11-deoxycortisol to cortisol resulting in a stimulation of hypothalamic CRF and ACTH and subsequent accumulation of 11-deoxycortisol (Fiad et al, 1994).
Taken together, our and others5 observations indicate that FAT/CD36 is a major LCFA protein transporter, which is responsible for augmented fatty acid uptake especially in VAT depot and subsequent accumulation of TAGs, as energy storage.
Se water contamination and subsequent accumulation in wildlife is a serious problem in the Central Valley of California, and the subject of increasingly intensive regulatory action.
Elevated soil concentrations in Scandinavian soils provide further evidence of the potential of increased scavenging by forests and subsequent accumulation by organic-rich terrestrial surfaces.
Farber disease is a rare lysosomal storage disorder (LSD) caused by a deficiency of acid ceramidase (AC) activity and subsequent accumulation of ceramide.
Fabry disease results from a deficiency in the activity of α-d-galactosidase A and subsequent accumulation of neutral glycosphingolipids in lysosomes.
Understanding the complex load transfer mechanism and the subsequent accumulation of deformation in ballast and subballast layers under repeated wheel loading is essential to design resilient rail tracks.
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CEO of Professional Science Editing for Scientists @ prosciediting.com