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Such interactions are frequently modulated by phosphorylation, which requires disorder in the target protein both for optimal kinase accessibility and for subsequent accessibility of the binding motif [44], [45].
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Drying is known to have an impact on subsequent enzyme accessibility but was a necessary preparation for analytical measurements following hydrothermal treatment [ 40].
The subsequent step, accessibility of the scientific data to the general public including health professionals and policymakers, is even more crucial and requires a translation that often is lacking.
Both MMP-1, capable of cleaving intact collagen [ 44], and MMP-3, responsible for the cleavage of other extracellular matrix components [ 45, 46] and the subsequent increase of accessibility of collagen fibrils to other collagenases like MMP-1 [ 35, 42, 47], are presumed to be of major importance in the initial joint destruction in the pathogenesis of RA.
Even though our approach is not consistent with the procedure for linking items to the ICF as described by others (see e.g. [ 28]), using the ICF as a guiding conceptual framework contributed to the development of further knowledge on how health-related domains are related to environmental barriers and the subsequent generation of accessibility problems.
The effects of future funding for motorways and local, regional and national roads have been modelled explicitly by taking into account future changes in traveltimes and their subsequent effects on potential accessibility.
Conversely, deacetylation strengthens DNA-histone interactions, decreasing DNA accessibility and subsequent gene expression [ 30].
Subsequent growth was due to accessibility to other ports (especially Philadelphia, 25 miles [40 km] northeast), abundance of waterpower in nearby creeks, and the fertility of nearby farmlands.
Consequently, the increase in the attitude accessibility facilitates customers' subsequent purchasing behavior (Downing et al. 1992; Morwitz et al. 1993).
For decades, pretreatment research has focused on chemistries and processes which selectively or effectively remove hemicellulose and lignin from the plant cell wall to increase enzyme accessibility to and subsequent hydrolysis of cellulose to glucose.
Such a pretreatment using an organic solvent miscible with water, followed by its subsequent replacement by water, ensured pore accessibility to water.
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