We hypothesize that, in the R11/R11 homozygote, independent initiation of transcription at the P2 promoter drives exon 4−5 transcription during development that is suboptimal for viability (Table 2).
Conclusion: Expression profiling identified genes involved in apoptosis and stress response pathways that are associated with poor cell viability caused by suboptimal handling; and provides candidate pathways to target with inhibitors of cell death to improve cellular recovery and function.
However, the outcomes of existing treatments have not been satisfactory owing to suboptimal localization to implantation site, poor viability, low engraftment efficacy and lack of functional remodeling of the delivered cells.
A suboptimal radiation dose that decreased cell viability by approximately 15-40% was chosen to use in further experiments, to obtain a large window for clear observation of the effect, if any, of the experimental treatment.
Csk1, although not essential for viability, is required for growth in suboptimal conditions or in the absence of normal Mcs6 complex function.
Corresponding Editor: Anna Rosling 'Exposure of cells to suboptimal growth conditions or to any environment that reduces cell viability or fitness can be considered stresses' (de Nadal et al. 2011).
For viability measurements, if the theoretical maximum effect (Einf) is suboptimal and therefore does not reach zero or 100% (depending on whether the stimulus promotes, or inhibits cell death, respectively), then there must be heterogeneity in the cell population.
Alternatively, the reduced viability of Coil −/− embryos might be due to a suboptimal uterine environment in the mother.
However, under suboptimal conditions or upon perturbation, organisms must maintain homeostasis and adapt their modes of operation to ensure viability [ 2].
"This coffee is suboptimal".
Her instincts are suboptimal.
