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These settings of the reference throughout value lead to either a too high or too low number of UEs steered to WLAN and therefore a suboptimal usage of the available network capacity.
Secondly, paths of different tunnels can run over the same link, which leads to contending congestion mechanisms over this link, resulting in a suboptimal usage of the link capacity.
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Why a virus that has evolved to replicate in human cells would maintain suboptimal codon usage is unexplained.
The sequences of wild-isolate strains of Human Immunodeficiency Virus-1 (HIV-1) are characterized by low GC content and suboptimal codon usage.
We propose that this value represents the actual difference in translational efficiency due to suboptimal codon usage by clinical-isolate HIV-1, although we also cannot rule out a possible contribution of altered cytoplasmic mRNA stability based on available data.
We conclude that suboptimal codon usage by HIV-1 results in only a slight loss of gag translational efficiency per se, with the vast majority of enhancement in protein expression from DNA vectors due to altered processing and export of nuclear RNA.
Less bias is expected when purifying selection fails to remove slightly deleterious mutations with suboptimal codon usage.
Work on poliovirus and T7 have both shown that different forms of engineered suboptimal codon usage can attenuate quantitatively to arbitrary levels.
As it has been shown that suboptimal codon usage in HIV is usually uncorrelated with translational efficiency [ 36], the reason for the conservation remains unknown.
Similarly, the number of phages detected in the blood culture samples is also likely a minimal estimate because of virus decay and possible suboptimal indicator host usage.
Data confirmed high risk or direct contact with influenza patients and their respiratory samples as independent risk factors for seroconversion (Table 4), yet suboptimal surgical mask usage or hand hygiene as independent risk factors, obviously because high- or low-risk participants had good adherence to PPE usage (100% for high- and 70.2-87.7% for low-risk).
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