Minimally invasive endourological treatment options for secondary UPJO have suboptimal success rates; hence, there is a re-emergence of interest about redo pyeloplasty.
Talc pleurodesis is the conventional management but requires hospitalisation (and substantial healthcare resources), can cause significant side effects, and has a suboptimal success rate.
Although the predictive values of demography and cardiometabolic health on A1C improvements were not unexpected, the suboptimal success in A1C realization is intriguing because a quarter of the patients were already or subsequently placed on three or more AHAs at baseline.
Although a great public heath success, vaccines provide suboptimal protection in some patient populations and are not available to protect against many infectious diseases.
Indeed, obtrusive males may reduce female fitness in a variety of ways [ 25, 26, 63] ranging from physical damage to inhibiting foraging success, resulting in suboptimal fecundity; e.g. bees [ 64], damselflies [ 52].
It is possible that this is due to the smaller sample size, but the fact that all eradicable foci were removed from our patients and that 94% of patients received empiric antibiotics active against MSSA probably also contributed to the relative success of using suboptimal therapy.
Immunization success rates are still suboptimal and treatment options bare considerable undesired side effects and drug resistance development.
Based on measurable performance differences, both in terms of increased hunting success [ 20] and suboptimal acceleration performance [ 46], as well as multiple instances of convergence in distantly related fishes, it seems unlikely that an increasingly elongate body was a neutral by-product of increasing vertebral count based solely on size and temperature.
However, the finding that intubation using RSI even with suboptimal dosage of paralytics demonstrated a higher success rate than that using non-RSI supports the favorable effectiveness of RSI.
In this context, we speculate that the composition of the adjuvant can be of utmost importance for the success of a vaccine, e.g., suboptimal concentrations of CpG or combinations of different adjuvants with well defined immunogenic antigens can be detrimental, need to be avoided; and recently reported superior adjuvants [ 7, 8, 11, 13, 36, 37] should preferentially be used.
Despite considerable successes, target-based approaches remain suboptimal in that they are often laborious, time-consuming, and susceptible to bias arising from factors such as unexpected off-target effects and collective effects by multiple targets.
