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These organisms can be resistant to all of the currently available antimicrobial agents or remain susceptible only to older, potentially more toxic agents, such as polymyxins, leaving limited and suboptimal options for treatment [ 2].
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Focal ablative therapy may be a suboptimal option for anterior prostate cancers (APCs) reaching the prostate apex due to concerns for thermal injury to the external sphincter.
TKA may represent a suboptimal option in terms of implant longevity in the former group and in terms of comorbidities in the latter.
Rats were then tested far beyond the indifferent point (i.e., 17%, 14%) when LLL became a suboptimal option and the economic benefit is attained unequivocally by choosing repeatedly the small-reward option.
On the contrary, the "gamblers" maintained a significant attraction for LLL, even beyond the indifferent point, when LLL became a suboptimal option (strategy × session: F 6,102) = 7.47, P < 0.001; Figure 2).
Such a strategy gains even more impetus since tumor suppressors such as DLC1 are generally not amenable to direct therapeutic targeting and blocking of Rho by geranylgeranyltransferase inhibition appears to be a suboptimal option due to the widespread cellular distribution of geranylgeranylation of proteins.
Mfold presents dot plot diagrams based on the minimum free energy of the suboptimal folding options of the sequence, where each folding option square is painted with a different color.
These pathologies cost the global healthcare system over $8.6 billion and affect 100 million patients annually.1,2 Unfortunately, knowledge of processes regulating dermal wound healing is still incomplete, which leaves patients with suboptimal treatment options.
Number of suboptimal folding options to be considered by the algorithm.
Treatment of NP in the past mainly consisted of regular analgesics, suggesting patients are receiving suboptimal treatment options [ 21].
This dot plot represents the secondary structure of one of the suboptimal folding options of a mutated sequence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com