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The Associate Editors and members of the Editorial Board were invited from many corners of the globe in order to represent a balanced appraisal of submissions which may reflect regional variations in approaches to trauma and limb reconstruction.
In England & Wales ,patient and carer groups can make evidence submissions which may provide perspectives from patients on experiences, preferences and expectations (p. 23) [ 37].
In Scotland, patient interest groups can make information submissions, which may include "patient views on treatments and medicines" (p. 1) and "preferences" (p. 1) [ 38].
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The EAC will produce a report based on this evidence and any additional evidence that was not part of the original manufacturer's submission, which may involve additional review/meta-analyses and/or economic modelling.
In Leiden and Amsterdam, protocols are reviewed by science committees before submission to the REC, which may reduce the time needed by RECs to review methodological aspects.
Routinely collected samples also overrepresent some age groups, as demonstrated by differential fecal submission rates (Table 1), which may not reflect age groups at greatest risk for infection by specific pathogens or risk for the overall population.
Future runs of DREAM will encourage simultaneous submissions of networks and predictions, which may help us close-in on the macro-level goal of DREAM, to learn new biology from the aggregate predictions of the systems biology modeling community.
It is likely that some health research system managers did not feel comfortable with applying the conceptual framework to their implementation plans (a lack of 'skill') and/or were not convinced of the benefits of utilising our hybrid framework and subsequent information architecture (a lack of 'will'), which may have lowered submission rates of performance dash-cards.
(2) Does the submission of data to a central registry, which may subsequently be linked to other data sources, require review by the institutional review board (IRB) of each participating organization?
Most of these submissions reported only a subset of affected genes, which may be acceptable, although all data should be available upon request.
At the time of submission we were not privy to these data, which may reflect either an increasing literature on the importance of NLR or alternatively a positive publication bias in retrospective series.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com