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Over the past few years, Disease Models & Mechanisms (DMM) has witnessed an increase in high-quality research submissions reporting advances in drug discovery and development.
Reasons for accepting submissions reporting ICERs above the threshold included high clinical benefit over the standard of care, and addressing an unmet therapeutic need.
Nevertheless, submissions reporting a higher-than-threshold base-case ICER must be supported by transparent, robust, and concrete evidence in order to achieve patient access.
For example, the Journal of Medicinal Chemistry frequently receives submissions reporting hits from experimental or computational (virtual) screening campaigns with PAINS liability (and is currently taking appropriate measures to tackle these problems, in collaboration with Jonathan Baell).
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However, all of these submissions reported ICERs in line with the threshold.
Most of these submissions reported only a subset of affected genes, which may be acceptable, although all data should be available upon request.
Supporters of paper submissions reported higher response rates, while proponents of electronic surveys felt that they provide the opportunity to tailor evaluations to different stakeholders.
Interestingly, while a large number of these submissions reported ICERs higher than the threshold, the proportion of accepted submissions in this category did not differ significantly to that in other disease areas, based on the outputs of the funnel plot and chi-square test.
Submissions not reporting an ICER, or for which an ICER could not be determined were also excluded.
Specifically, beginning on 1 January 2013, we will require all submissions to report HbA1c levels in both traditional units (i.e., reported as %, derived Diabetes Control and Complications Trial [DCCT] units) and Système International (SI) units (reported as mmol/mol).
The date of sample collection from the herd was identified from the diagnostic-sample submission report.
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CEO of Professional Science Editing for Scientists @ prosciediting.com