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The spirochete isolates were obtained by culture from clinical submissions of tissue samples transported in isotonic saline or swabs transported in Amies.
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Submission of tissue samples was not mandatory, and EGFR protein expression was only detected for 57.3 % of the full analysis set population.
A potential limitation to the biobank is that submission of tissue and blood samples is optional and this may impact the exploratory analyses performed in the future.
However, if local policies did not permit submission of a tissue block, 10 serial unstained sections could be submitted.
Upon submission of the tissue or data request, the NNTC steering committee reviews it, and potentially suggests modifications, in order to ensure proper stewardship of the resource.
The predicted diagnosis was based on the correspondence from the nephrologist who performed the biopsy to the patient's primary physician or was based on the clinical diagnosis recorded on the biopsy report at the time of submission of the tissue sample.
Submissions of animals for necropsy or tissue for histology were classified as 'pathology' submissions.
Because FFPE tumor samples provide reliable results on 450K array testing, mandating submission of fresh-frozen tissue raised an ethical conflict, given the implications that knowledge of subgroup has the potential to more accurately guide treatment (e.g., reduced intensity of CSI in patients with WNT medulloblastoma).
Stephens and Dimond (2015) explore the impacts of unanticipated happenings at a biobank, specifically focusing firstly upon significant increases in tissue submissions and secondly upon unexpected biobank closure and the subsequent redistribution of tissue.
Infectiveness of tissue.
Submissions of powder and nonpowder environmental samples and human blood or tissue specimens submitted from October 8 through December 31 , 2001 were reviewed.
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