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At 47 million, PubChem is not only the largest open repository but also provides content counts by submission types that can be used to answer (b) and (c) [6].
A possible reason for this is the way in which submission types are assigned and the fact that review criteria are tailored to each submission type.
If there was a mismatch in the submission types selected by the reviewers, the abstract would be rated on different Methods criteria.
To date, we have encountered 23 different submission types, including: ChIP-seq and ChIP-chip investigations of TF or other binding sites, replication timing, histone modification and chromatin structure, gene annotation, 5′- and 3′-RACE, targeted RTPCR, and RNA tiling array and RNA-seq to identify transcription levels.
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Reviewers did not always agree on the type of submission type, however.
There was no apparent difference in the mycobacterial species isolated at different times of the year or by submission type.
Isolates were tabulated by the region of the United States from which they originated and by submission type.
In 2001 and 2002, each reviewer selected the submission type (i.e., "survey") upon which the review criteria were based.
Starting in 2003, the CAEP Research Committee requested that authors select their submission type so the same Methods criteria would be utilized by all three reviewers.
The following information was obtained from the NVSL databases; accession number, date sample received at NVSL, submission type (abattoir or field), result of mycobacterial identification, species or source of sample, histological result, and the state of origin.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com