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At the time of submission of this study protocol participants were still being recruited.
Upon submission of this study, four reports on Gram-positive bacterial RNA sensing by hTLR8 or on mTLR13 structure have been published and largely summarized [ 26– 30].
HS-G participated essentially in establishment of laboratory analyses, their evaluation and statistics, but unfortunately died before submission of this study.
In response to the submission of this study to the Northern Territory Government the Minister for Health clarified the policy and funding responsibilities within and between governments for this type of public health intervention, including systems of management and accountability.
Special thanks are due to Jennifer C. Johnson, Mawuli Gyakobo of the University of Ghana, and Peter Agyei-Baffofr of the Kwame Nkrumah University of Science and Technology, for assistance with the submission of this study for ethical review.
GZ participated in planning of the study, evaluation of patients, data and statistics and has seen and approved the final version, HS-G participated essentially in establishment of laboratory analyses, their evaluation and statistics, but unfortunately died before submission of this study.
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Centralized Institutional Review Boards (New England Institutional Review Board in 2007 and Copernicus Group Independent Review Board from 2008 to 2011) approved the studies and iterative submission of study documents (study protocol, interview guides, patient information and informed consent form, and health information and demographic form).
12 13 Investigators, who followed research projects from the moment of the submission of the study protocols to ethics committees and medical agencies to the publication of the results, demonstrated that statistically significant and positive results often have a multiple times higher probability to be published than other results.
The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2407/12/615/prepub Until submission of this manuscript, this study is supported by the initiative "Highly Specialized Medicine"of the Kanton Zurich, Switzerland.
Since the first submission of this paper, two studies on general purpose search engine queries have been published; one based on Google search queries [11] and one on Yahoo! search queries [12].
Following the completion of our study and the submission of this manuscript two important studies have been published which directly relate to our findings [ 31, 32].
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