Centralized Institutional Review Boards (New England Institutional Review Board in 2007 and Copernicus Group Independent Review Board from 2008 to 2011) approved the studies and iterative submission of study documents (study protocol, interview guides, patient information and informed consent form, and health information and demographic form).
Since replicability is a purely technical aspect, it would ideally be verified upon submission of a computational study, as part of the reviewing process.
Yet this was known at the time of submission of our study.
At the time of submission of this study protocol participants were still being recruited.
HS-G participated essentially in establishment of laboratory analyses, their evaluation and statistics, but unfortunately died before submission of this study.
Upon submission of this study, four reports on Gram-positive bacterial RNA sensing by hTLR8 or on mTLR13 structure have been published and largely summarized [ 26– 30].
Special thanks are due to Jennifer C. Johnson, Mawuli Gyakobo of the University of Ghana, and Peter Agyei-Baffofr of the Kwame Nkrumah University of Science and Technology, for assistance with the submission of this study for ethical review.
In response to the submission of this study to the Northern Territory Government the Minister for Health clarified the policy and funding responsibilities within and between governments for this type of public health intervention, including systems of management and accountability.
A recent German observational study on VKA-OAC (n = 1,176), published after the submission of our study, suggested that rapid reversal of INR is associated with less ICH expansion and lower in-hospital mortality, but was not powered to compare reversal therapies due to a uniform national practice of using PCC.
12 13 Investigators, who followed research projects from the moment of the submission of the study protocols to ethics committees and medical agencies to the publication of the results, demonstrated that statistically significant and positive results often have a multiple times higher probability to be published than other results.
