Therefore we assessed study population characteristics, such as number of included subjects; definition of potential CRC risk factors; whether subjects were consecutively recruited; mean or median age with age range and sex distribution (a).
A total of 21 studies [ 24- 45] fulfilled the inclusion criteria and were further assessed with regards to setting, inclusion criteria of study subjects, definition of exposure and outcome, mechanisms for ascertainment of exposure and outcome, and confounders controlled for (table 1).
A total of 38 (31%) of 124 tested subjects had a positive AFB smear or mycobacterial culture; these subjects meet a study definition of definite or probable TB (Table 1).
Reference intervals for the Gaussian between-subjects definition for LSMDs appear in Table 5.
Relative contribution of each segment to total lumbar motion and the reference intervals for the normalised within-subjects definition in Table 6.
Under the normalised within-subjects definition we found a higher prevalence (29.8% for rotational LSR, 35.5% for translational LSR), with most problems at the lower lumbar levels, a finding concurrent with Mayer's description [ 3].
The reference intervals for the conventional Gaussian between-subjects definition of abnormal was achieved by calculating the 2sd range for each segmental level (L2-3 to L5-S1) from the asymptomatic sample [ 41].
The reference intervals for the normalised within-subject definition of abnormal were defined by the 2sd range of the relative (proportional) contribution of each segmental level towards the total lumbar motion, for each of the four levels within each individual.
The file outputs were then parsed according to their respective informative fields (query name, query size, subject name, subject size, subject definition, score, bitscore, expected, identity, similarity, gaps, first base of query homology, last base of query homology, first base of subject homology, last base of subject homology) using Perl.
To balance these imperatives – maximizing benefit of SRI, minimizing the risk of high dose SRI, and minimizing unnecessary delay in implementing augmenting treatment, a "within subject" definition of "adequate dose" that included both dose-response and time-response considerations was implemented.
The secondary case definition included subjects (a) fulfilling the primary case definition or (b) with a pathology report stating 'Barrett's', without a description of the type of metaplasia.
