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In conclusion, type 1 DM patients without hypertension showed WM and GM volume loss compared with healthy control subjects concomitant with a relative increased brain perfusion.
Type 1 DM patients without hypertension showed WM and GM volume loss compared with control subjects concomitant with a relative increased brain perfusion.
The subjects' concomitant medication was stopped at 9.00 p.m. on the previous day to allow a washout time of 12 h or more before the measurement of cough threshold to inhaled capsaicin at 10.00 a.m. on each test day to reduce the diurnal variability of cough response.
The main findings of our study were: 1) type 1 DM patients showed WM and GM volume loss compared with healthy control subjects concomitant with a relative increased brain perfusion; 2) total CBF and stiffness of the aorta independently predicted WM brain atrophy; and 3) age was the only independent predictor of GM brain atrophy, whereas tCBF and aortic PWV were not.
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The present results confirmed our previous findings that cattle grazing in an anaplasmosis-endemic field were subject to concomitant infection with both the vaccine A. centrale and the field A. marginale strains.
The frequency of subjects with concomitant use of respiratory system therapies was lower for the 100 mg BID group (42.9 %) compared with the placebo, 50 mg QD, and 100 mg QD dose groups (60.0, 50.0 and 75.0 %, respectively).
As in the double-blind treatment phase, the frequency of subjects with concomitant use of respiratory system therapies was lower for cohort 3 (42.9 %) compared with the cohorts 1 and 2 (88.9 and 80.0%%, respectively).
Indeed, even in well-defined experimental settings such as virtual reality paradigms, the use of either representation may vary across subjects with concomitant recruitment of distinct neural substrates [33], [34].
All subjects received concomitant treatment with aspirin 75-100 mg/day.
Three subjects took concomitant medication (naproxen, acetyl salicylic acid, ibuprofen and articaine).
A major impediment to investigating metabolic consequences of OSA is inclusion of subjects with concomitant prediabetes.
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