And 6 trials were selected from all the 10 trials according to the state of the subjects (concentration, movement of the body, etc).
Study subject concentrations of CoQ10, F2-isoprostanes, and isofurans were also compared to concentrations in non-dialysis historical control subjects.
Individual subject concentration-time data were evaluated using a noncompartmental analysis approach as implemented in WinNonlin version 6.3 (Pharsight Corporation, USA).
Interactive graphics create an integrated framework to link the parallel coordinate plot, the MDS plot, and the plot of the subject concentration profiles.
Negligible numbers of subjects had concentrations >150 nmol/L, and only 1% of the population had concentrations >120 nmol/L.
In most subjects, plasma concentrations of glucose, insulin, glucagon, cortisol, homocysteine, glycerol, and C-reactive protein were within reference ranges.
In sham-perfused subjects, steroid concentrations in plasma, whole blood, and brain at sacrifice were compared within individuals (Fig. 4).
In elderly as well as younger subjects, plasma concentrations were comparable.
The proportion of subjects with concentrations below the LOD was calculated for each chemical metabolite.
After the booster dose, the percentage of subjects with concentrations ≥10 mIU/ml was between 97.7% and 100%.
