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Data were subject to normalisation and regression steps as described in detail in our earlier work [ 13].
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All datasets (endothelial and neuronal, disease and control samples) were subjected to normalisation and quality control measures together, within each array platform.
CEL file data were subjected to normalisation by GCRMA.
Our normalised DDCs are by definition unbiased, and not subject to numerical normalisation noise.
The class weights, w, reflect the importance of a class and are subject to the normalisation ∑ j w j = 1.
The bulk viscosity, subjected to a normalisation, is shown to be approximately a unique function of density.
Data from each microarray study were subjected to global normalisation.
Illumina probe profile expression values were subjected to quantile normalisation using the lumi package.
The first step is to map the reads to the genome or transcriptome, and then the number of reads aligning to a specific region of the reference sequence is counted and subjected to relevant normalisation procedures [ 35].
The data were then subjected to quantile normalisation to allow for the identification of significant differences in H3K27me3 promoter reads between the two developmental states using the statistical tools in the CLCBIO package (CLCBIO).
Data from each microarray study were subjected to a global normalisation (Sugimoto et al, 2009).
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CEO of Professional Science Editing for Scientists @ prosciediting.com