"subject to internalization" is a correct and usable phrase in written English
It is typically used when discussing a concept or idea that needs to be fully understood and embraced by an individual or group. Example: The new company policy, subject to internalization by all employees, aims to promote a more inclusive and diverse work environment.
Fluorescent ligands were reported previously for other P2YRs (P2Y2,4,6), but these are nucleotide agonist analogues that are subject to agonist-promoted internalization.
In this current study, we determined that the hIP is subject to agonist-induced internalization mediated, at least in part, via a dynamin- and Rab5a-dependent route, requiring GDP/GTP exchange on Rab5a for hIP trafficking to endosomes.
Interestingly, while the heparanase-syndecan complex is subjected to rapid internalization and appears in endocytic vesicles short after the addition of heparanase, the KKDC peptide elicits syndecan clusters that remain on the cell surface for a relatively long period of time and fail to get internalized.
Our previous results (Yesilaltay and Jenness, 2000) showed that Ste2-T326-GFP Ste2-T326-GFP Ste2-T326-GFPisduced inotrnalization in absubjectf co-expressed receptors.
However, such chemical delivery systems can be associated with cytotoxicity and drugs administered by that route can be subject to lysosomal degradation after internalization.
While both TP isoforms undergo rapid agonist-induced phosphorylation in response to TXA2 mimetic U46619 [20,25], TPβ, but not TPα, is subject to GRK/β-arrestin-dependent internalization following prolonged agonist exposure [37,38].
Finally, we make the simplifying assumption of co-modulation [2], [5], considering all TCR within the synapse as subject to the same rapid induced internalization.
The antibody-drug conjugate (ADC) contains a peptide linker (valine citrulline) that is subject to cleavage by lysosomal enzymes following internalization into target cells (Francisco et al, 2003).
Its endocytic internalization and intracellular trafficking are subject to amino acid control.
In addition to disappearing via receptor-mediated internalization and blood clearance, VEGF is subject to proteolysis by plasmin and matrix metalloproteinases.
