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Exact(4)
Moreover, gene deletion and pseudogene formation events are rare, except among genes that have also been subject to duplication [ 4- 6].
In support of this, all publicly-available mammalian genomes contain a single annotated RUNX2 locus, suggesting that this gene has 1 1 orthology across mammals and has not been subject to duplication.
In the duplication-divergence model one would not expect length-dependence over time, since long and short genes should be equally likely subject to duplication at any time level.
A dot plot of human versus gorilla genomic sequence from HLA-F to HLA-J (Supplementary Figure S1) suggests that stretches of sequence within this region have been subject to duplication and re-arrangement after the divergence of gorilla and human.
Similar(56)
It is believed that dinoflagellate genomes have been subject to duplications of individual genes or segmental to whole genome duplication [5], [39], or combinations of these mechanisms.
Family members are frequently found in four paralogous regions, which were formed in two rounds of genome duplication in the early vertebrates, but in some species class Is have been subject to additional duplication or translocation, creating additional clusters.
Finally, the purD:: lac region is subject to frequent duplication.
Alternatively, the multiple gene families may correspond to genes subject to recent duplication events.
In addition, they are subject to frequent duplication, deletion and pseudogene formation [ 40].
The remaining ~10% of genes are subject to frequent duplication, deletion and pseudogene formation [ 4- 6].
Genes that are typically transferred by HGT are those that are constantly subject to gene duplication and gene loss.
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