Suggestions(1)
Exact(5)
The palliative benefits reported in our trial are consistent with the reported literature subject to dose and fractionation.
However, injections were also seen as unpleasant, painful, limiting on travel and time, a source of anxiety and fear, associated with allergies and subject to dose variability.
Both CsA and tacrolimus are subject to dose reduction protocols [ 1], which inevitably makes variability in exposure an issue for both drugs.
In phase II of the study, the dose administered was the MTD as defined in phase I, subject to dose modification in the event of toxicity as described below.
In our material, most patients that were subject to dose adjustments after the switch to generic tacrolimus showed a trend of change in tacrolimus trough concentrations even before the generic conversion.
Similar(55)
The trial used a standard 3 + 3 dose escalation design as previously described, with only the HCQ dose subject to dose-escalation rules.
Nineteen patients (53%) were subjected to dose reduction owing to adverse events.
Two patients were subjected to dose reduction owing to adverse events.
However, our experimental data imply that when used singularly the anti-inflammatory activity of CWE is subjected to dose ranges.
Four patients were subjected to dose reduction by one step, and two patients were by two steps due to grade 3 adverse events.
PolyNIMMO dissolved in halogenated and aromatic solvents was found to undergo structural changes when subjected to doses of gamma radiation up to 250 kGy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com