Exact(4)
Chemoradiotherapy using both docetaxel and cisplatin has been the subject of phase I trials in NSCLC.
This is the subject of phase 5 of the IOTA study, for which data collection started early in 2013.
Sildenafil, which corrects F508del- CFTR trafficking and increased chloride transport in F508del- CFTR mice [ 10], is the subject of phase 1/2 clinical trials [ 8].
As single agent, bevacizumab, the monoclonal humanised antibody against VEGF-A, yielded response rates of 15.9 and 21.0% in refractory ovarian cancer patients in phase II trials and is currently the subject of phase III trials (Burger, 2007; Burger et al, 2007; Cannistra et al, 2007).
Similar(56)
The characteristics for participating subjects of phase 2 of the study are described in Table 5.
The final population PK model was obtained using 1,742 plasma PK samples (237 subjects) of phase I−III studies.
This means that the calculated PAL (TEE/BMR) by using the measured BMR would include a potential underestimation by 4%5%% in the subjects of Phase 2 study.
Subjects of phase 2 had to discontinue the use of plant sterol or stanol products or fish oils at the inclusion visit and statin treatment 6 weeks (40 days) before the start of study treatment.
Subjects of phase 1 were not allowed to use any lipid-lowering drugs at inclusion, and the use of plant sterol- or stanol-containing products had to be discontinued at the inclusion visit.
SR4554, has shown considerable promise in animal models (Aboagye et al, 1997, 1998 Seddon et al, 2002a) and is currently the subject of a Phase I/II Committee Phase I trial in which MRS is used in patients to detect SR4554-derived sindicativeicative of tumour hypoxia (Seddon et al, 2002b).
The results of phases 1 and 2 were included in a three-way anova, with a between-subjects factor of group and within-subject factors of phase and block.
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