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All except one subject converted to a negative sputum smear at 2 months of treatment (Table 1).
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Those individuals scoring above this cut-off are at high risk with every fourth subject converting to AD within the observational period.
A 12 months follow up was used to determine whether MCI subjects converted to AD (MCI converters) or remained clinically stable (stable MCI).
Forty-seven per cent of PIB-positive subjects converted within 1 year, and these early converters showed higher tracer retention in the anterior cingulate and frontal cortex than late converters.
At longitudinal follow up of up to 3.5 years (mean 2.5±0.79 years), 11 MCI subjects converted to AD.
Among CN, 14 subjects converted to MCI and 2 to AD.
Only 1 of 14 (7%) amyloid-negative subjects converted in the same time period.
Thus, a questionable interpretation of data from patients with CKD and the subsequent extrapolation to healthy subjects converted a hypothesis into nutritional recommendations for the prevention of osteoporosis.
In the total ADNI-1/GO/2 cohort, 43 (8.8%) of the CN subjects converted to MCI, 10 (2.1%) converted to DAT (8 had an MCI diagnosis before the DAT) and 11 (2.3%) died (Table 1 and Additional file 1: Table S2).
Among MCI, 59 subjects converted to AD and were labeled progressive MCI (pMCI), while 165 subjects did not convert to AD (during at least 2-year follow-up) and were labeled stable MCI (sMCI; these also included five subjects who reverted from MCI to CN).
11 However, not all MCI subjects convert to AD and therefore predicting converters would be useful for the clinician and for the patient and their carers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com