Within each cell type, cell lines derived from the same subject clustered more closely together than to the cell lines from different subjects.
In AA subjects, clustering of module-trait correlations indicated the strongest overlap between SI- and AIRg-associated modules.
Given a sample size of 146 subjects, clustering combinations that produce large numbers of clusters, e.g., 50, offer limited ability to learn mechanistic information because each cluster is limited to a small number of subjects, e.g., three.
V1-V3 sequences from all subjects clustered with subtype B reference sequences.
Of note is that healthy control subjects cluster together at the left side of the graph.
Multidimensional scaling analyses based on pairwise IBS showed that, apart from some outliers, all subjects clustered closely with HapMap Asians.
The PCA also gives the opportunity to multivariately investigate how subjects cluster into subgroups and how certain subgroups differ.
Regression techniques that take clustering into account [ 3- 6] are frequently used in cluster randomized trials and in etiologic research with subjects clustered within e.g. neighborhoods or countries.
Principal components analysis showed that C. leptum from most of the control subjects clustered discretely to one side whereas C. leptum from CD and UC patients clustered separately.
This approach groups masses based on their similarity of intensity between samples, meaning that masses with related fold-changes between subjects cluster together, independent of their absolute levels.
