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Another major subitem of validity is internal validity, which deals with the cause effect relationships, eg, the impaired nutritional status leads to poor outcome, and the nutritional support improves outcome, independent of the effect of the underlying disease.
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All subitems of frailty were significantly associated with increased risk of disability.
The results for the eight subitems of the MoCA differed in the subgroups of age, sex, and education level.
We will include two measures of social support at work and explore the relevance of subitems of the social support scale employed.
Finally, to explore the relevance of different aspects of social support, we performed subanalyses where we treated each of the subitems of the social support scale as separate outcomes.
Analyses for subitems of frailty showed that slowness (2.32, 1.62 to 3.33), weakness (1.90, 1.35 to 2.68) and weight loss (1.61, 1.13 to 2.31) were related to increased risk of disability incidence.
Our findings regarding the subitem scores of the older participants are comparable to the Italian data, except for the domains of attention and orientation [ 32].
Validity is composed of several major subitems, one of which is construct validity.
Interestingly, we found that none of the manuscripts described change of the methods after trial commencement (Subitem 3b), change of trial outcomes after the trial commenced (Subitem 6b), interim analyses and stopping guidelines (Subitem 7b), premature discontinuation of the trial (Subitem 14b) and additional analyses (Subitem 18).
However, compared with the before publication of the MOOSE Checklist, the quality of reporting improved significantly for 20 subitems after publication of the MOOSE Checklist, and 7 items of the included MAs demonstrated significant improvement after publication of the AMSTAR Checklist (p<0.05).
However, no study provided the name and version of the search software employed (subitem 11), and there was no mention of the special features used (table 5).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com