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This possibility remains to be investigated in the future using a larger sample size of this subgroup of tissues.
A subgroup of tissues showed only moderate reduction of expression, although GATA5 methylation was detectable, indicating that other biological mechanisms, e.g. histone alterations, play a role in tumor development in ccRCC.
In the current study, we demonstrate that GATA5 mRNA expression is strongly reduced in ccRCC and, moreover, that a subgroup of tissues shows a clear relationship between methylation of the GATA5 CGI and reduced mRNA expression, indicating that epigenetic silencing of GATA5 occurs in a substantial fraction of ccRCC.
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A niche is a subgroup of tissue cells and extracellular substrates that can indefinitely harbor one or more stem cells and control their self-renewal and progeny in vivo [ 3].
In fact, only few subgroups of tissues were available which had obvious related biological functions.
Haemocyte genes displayed unique features that were distinct from those of the three subgroups of tissues described previously.
In the supplementary material (Additional file 1) we present the results of global overrepresentation and of local GSZ-enrichment analysis applied to the respective subgroups of tissues.
Our method was able to detect a novel split of the signal for splicing changes in CNS tissues into two separate subgroups of tissues, and a previously unreported AS signal associated with digestive tissues.
First, in order to clarify the prognostic values of miR-200c in different source of samples, we classified the enrolled studies into subgroups of tissue samples and serum/plasma samples.
Figure 2 shows the correlation between mtDNA copy number from quantitative PCR and mean mtDNA base read depth from WES; correlations for subgroups of tissue type, capture target, and WES data batch are also shown.
Rhabdomyosarcomas (RMS) are rare [1] malignant diseases that form a subgroup of soft tissue sarcomas (STS) which affect primarily children and young adults [2].
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