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Three clusters were defined as a result of the PCA analysis; cluster 1 corresponded to class I PPIs, while class II PPIs were subdivided into two clusters.
Cluster II was subdivided into two clusters, IIa and IIb, with relatively high supporting values.
Group C was subdivided into two clusters, C1 (69%) and C2 (31%); these were distinct clusters with genetic distances of 0.3 and 0.34, respectively.
The NEP lineage was further subdivided into two clusters which were however geographically intermixed between the samples from Washington and Gulf of Alaska (WAS, ALA).
The Beijing family strains (n = 190; 69.34%) were subdivided into two clusters and 185 unique patterns, while the non-Beijing family strains (n = 84; 30.66%) were subdivided into three clusters and 75 unique patterns.
The NEP lineage is further subdivided into two clusters, but with no geographical structuring; it is controversial whether this reflects a cycle of refugial isolation and remixing [ 17] or just random mtDNA coalescence within a single panmictic, large and old population [ 18].
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Group b can be subdivided into three clusters, B1, B2, and B3, indicated by ovals.
Subhaplogroup U5b is subdivided into three clusters, U5b1, U5b2 and U5b3 (Figure S2).
Cluster I, containing the majority of the accessions, could be further subdivided into three clusters a, b and c.
The PHP family within the amidohydrolase superfamily is further subdivided into three Clusters of Orthologous Groups: cog1387, cog0613, and cog4464.
Enterobacteria have been subdivided into three clusters on the basis of the character states of aromatic amino acid biosynthesis [ 59].
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