Lipoprotein subclass size varies between research groups, as does the number of subclasses reported, as categorisation of the lipoprotein subclasses is method dependent [57].
Among the lipoprotein subclasses, VLDL particle sizes are increased and LDL and HDL particle sizes are decreased in patients with insulin resistance or T2DM.
Assuming that TEs from the same subclass have comparable size in all Drosophila species, these data suggest that the rate of consensus fragmentation is about twice as high in D. pseudoobscura as in the other two genomes.
We measured dam and offspring body weight, plasma lipid parameters, lipoprotein subclass particle numbers and sizes, and total antioxidant capacities.
The lipid panel was tested by LipoScience Inc., (Raleigh, NC) using nuclear magnetic resonance spectroscopy (NMR) to assess the lipid subclass particle counts and sizes, and standard chemical methods (Beckman Coulter and performed on Olympus AU Systems) to measure total cholesterol, HDL-cholesterol and triglycerides.
From a mechanistic point of view, HDL cholesterol level is determined by two factors: first the number of circulating HDL particles, and second the mean cholesterol content per particle, i.e. its size or subclass distribution.
Adiponectin is favorably associated with lipoprotein particle size and subclass distribution independent of adiposity and insulin sensitivity.
Notably, a complete structure of size n is generated by recursively unranking the distinct structural components from the corresponding subclasses (of substructures with sizes less than n).
We evaluated the relationships of plasma adiponectin with lipoprotein mean particle size and subclass concentrations, independent of obesity and insulin sensitivity.
Our study is the first to examine the relationship between in vivo insulin sensitivity and lipoprotein particle size and subclass concentrations in children.
