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Lipoprotein subclass size varies between research groups, as does the number of subclasses reported, as categorisation of the lipoprotein subclasses is method dependent [57].
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This analysis is likely to uncover only very large effects with the present experiment given the smaller subclass sizes involved and the need for stricter testing thresholds to account for the increased number of multiple tests.
Here we divide the PRD class into two subclasses of unequal size: the PAX subclass (containing seven PAX genes, excluding PAX1 and PAX9), and the PAXL subclass (containing 43 non-PAX genes and many pseudogenes) (Table 1).
Assuming that TEs from the same subclass have comparable size in all Drosophila species, these data suggest that the rate of consensus fragmentation is about twice as high in D. pseudoobscura as in the other two genomes.
As of now there is overlap of the size subclasses and cells of origin [4, 5].
Insulin resistance is associated with marked abnormalities of lipoprotein size and subclass particle concentration.
From a mechanistic point of view, HDL cholesterol level is determined by two factors: first the number of circulating HDL particles, and second the mean cholesterol content per particle, i.e. its size or subclass distribution.
Adiponectin is favorably associated with lipoprotein particle size and subclass distribution independent of adiposity and insulin sensitivity.
We evaluated the relationships of plasma adiponectin with lipoprotein mean particle size and subclass concentrations, independent of obesity and insulin sensitivity.
Our study is the first to examine the relationship between in vivo insulin sensitivity and lipoprotein particle size and subclass concentrations in children.
In addition to traditional lipid profiles, evidence suggests that insulin resistance and type 2 diabetes are associated with changes in lipoprotein particle size and subclass concentration (2, 4).
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