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The explanans contains two subclasses: "one of these contains certain sentences C l, C 2, … C k which state specific antecedent conditions; the other is a set of sentences L 1, L 2, … L r which represent general laws" (Hempel and Oppenheim 1948, p. 137).

In the current study, we built seven subclasses, one for each taxonomic group.

A third possibility is that carcinomas fall into different subclasses, one of which is characterised by a high frequency of methylation alterations.

Interestingly, this analysis resulted in two main subclasses one of which had lower acetylation levels with the exception of H3K23ac (Fig.  4a, b).

The eukaryote APH3 sequences can be further divided into two broad subclasses: One of these, the APH3_ACAD subclass, occurs in nearly all eukaryotes and is associated with acyl-CoA-dehydrogenase enzymes (e.g., ACD10_HUMAN) (representative pdbid: 3dxp in Fig.  2).

The 22G-RNA class is further divided into two subclasses, one bound by CSR-1 and required for holocentric chromosome segregation (Claycomb et al. 2009), and the other subclass bound by worm-specific AGOs and playing an important role in transposon, pseudogene, cryptic locus, and protein-coding gene silencing (Gu et al. 2009).

The first subclass is one in which the source and relay are clustered, and the eavesdropper receives signals only on the channel from the source and the relay to the destination, for which the PDF strategy is optimal.

All analysis is carried out at both the class and subclass level (one level down from the class) to ensure that our findings and insights are persistent across different levels of detail.

The General Germplasm and Passport Ontology Subclass is one of the most important subclasses of the CO.

Each of these subclasses has one or two further layers of subclasses.

Recent studies indicate that IgG Fc-FcγR interactions are dynamically regulated during an immune response through the control of the Fc-associated glycan structure and Ig subclass composition on the one hand and selective FcγR expression on immune cells on the other, which together determine the capacity of IgG to interact in a cell-type-specific manner with specific members of the FcγR family.

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