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To overcome this limitation, targeted serum shift prediction models were generated for each subclass of interest and were applied to the design of prospective analogs.
At a coarser granularity (i.e., smaller number of larger candidate subclasses), a biological subclass of interest might be missed.
The 40 genes that showed the greatest mean difference in expression between the subclass of interest and the remaining subclasses was used as our predictor gene set.
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These promising results encouraged further research on relevant markers of thyroid tumors, taking into account more classes and subclasses of interest, as some authors have recommended [18].
Ideally, the counter-selection FRT-like sequences should come from a subclass, to which an FRT-like site of interest belongs, since all sequences in this subclass have identical functionally important proximal-8 region.
An L-retract is clearly a neighborhood retract of E and, in particular, is closed in E. The class of L-retracts is quite large and contains many subclasses of non-convex sets of interest in analysis and topology, e.g., closed subset of normed spaces that are bi-Lipschitz homeomorphic to closed convex sets, epi-Lipschitz subsets of normed spaces, prox-regular sets, etc. (see [59] and [11]).
PARE uses a non-linear score to classify gene pairs of interest into subclasses of various time lags.
From the output of the program, two FRT-sequences can be chosen as counter-selection targets: one from the subclass to which the FRT-like sequence of interest belongs, and one from the rest of the FRT-like sequences.
There exist problems for which the most efficient known decision algorithm has exponential time complexity in the worst case (and in fact are known to be \ \textbf{NP}\ -hard in the general case – see Section 3.2) but which operate in polynomial time either in the average case or for a large subclass of problem instances of practical interest.
A particular subclass of sequence variants of great interest and potential importance is the set of mutations whose deleterious effects on proteins are readily remediable by simple means.
Of interest is that molecular subclasses of breast cancer tend to express different families of CKs, which can be translated into different detection rates throughout the molecular subclasses when only one antibody against CKs is used [ 31].
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