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Mitochondria represent an attractive subcellular target due to its function particularly important for oxidative damage, calcium metabolism and apoptosis.
The translocator protein (TSPO) represents an interesting subcellular target not only to image disease states overexpressing this protein, but also for a selective mitochondrial drug targeting.
However, it has recently become increasingly obvious that cytosolic internalization of a drug molecule does not entail its interaction with its subcellular target and hence careful nanoparticle design and optimization is required to enable nuclear targeting.
Hence, it implicates that the proteins dynamics make the protein fate and subcellular target complicated and the experimental evidence supports has limited power to validate the computed predictions.
The subcellular target of the mtMutS mRNA, and the role of the gene product, remains unknown.
At present, no preferential subcellular target of Foscan® has been identified.
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Some drugs act on multiple subcellular targets.
In therapy, NPs may allow more effective cellular and subcellular targeting of drugs.
Therefore, mitochondria have been long deemed as the subcellular targets applied for cancer treatment in the previous reports [28].
The assembly and disassembly of viral structures, presentation of viral ligands, and the subcellular targeting of viruses are emphasized.
The separation of the classes likely reflects differences in the subcellular targeting of the two types of proteins.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com