Sentence examples for subcellular destination from inspiring English sources

To this end, various specific topogenic signals have been designed as well as highly selective protein translocation machineries that ensure that each newly synthesized polypeptide reaches its correct subcellular destination or, in case of secretory proteins, is exported to the cell exterior.

It is therefore highly interesting that: 1) The same mRNAs can adopt dramatically different subcellular localizations or become unlocalized in different cell types and 2) That mRNAs within one cell change their subcellular destination over time.

To infer dual targeting and to predict which subcellular destinations were shared, we first determined the single most likely subcellular destination for each protein based on information from multiple prediction programs.

Alternatively, the recent demonstration of the rescuing activity obtained by overexpressing the short β30 31 sequence of the human Cterm in the yeast model (Francisci et al, 2011) suggests that Cterm-derived peptides may be used as therapeutic agents, provided that suitable agents for mitochondria targeting are employed to deliver them to their subcellular destination.

Pharmacologic approaches to stabilize the partial misfolding using small molecule chaperones attempt to divert the mutant polypeptide from degradation pathways and deliver it to its native subcellular destination, ideally allowing a sufficient recovery of physiological function to prevent the disease state (28).

The levels and subcellular destinations of the transcripts are compared for transcripts expressed using the U6 small nuclear RNA (snRNA), 5S ribosomal RNA (rRNA), and the 7SL RNA component of the signal recognition particle.

Since emerging evidence indicates that TAG synthesis in microalgae operates through coordinated crosstalk between multiple pathways in diverse subcellular destinations including the endoplasmic reticulum and plastids, we discuss new experimental studies and models that incorporate these findings for discovering key regulatory checkpoints.

Organellar proteomes are determined through regulated pathways that target proteins produced in the cytosol to their final subcellular destinations.

We further employed WolfPSORT and Plant-mPLOC [ 46, 47], and obtained a range of predicted subcellular destinations.

In this report, we utilized fluorescent reporter protein fusions and immunolelectron microscopy to determine the subcellular destinations of CNGC19 and CNGC20.

An additional level of regulation involves signal sequences within proteins that mediate folding, trafficking to subcellular destinations and the formation of protein complexes.