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Further, l-arginine pretreatment with sub effective dose of lycopene significantly reversed the protective effect of lycopene.
However, l-NAME pretreatment with sub effective dose of lycopene significantly potentiated the protective effect of lycopene which was significant as compared to their effect per se.
Further, l-NAME (5 mg/kg) and methylene blue (10 mg/kg) pretreatment with sub effective dose of venlafaxine (5 mg/kg) potentiated its protective effect which was significant as compared to their effect per se.
Further, GABA (50 mg/kg) and/or muscimol (0.05 mg/kg) pretreatment with sub effective dose gabapentin (50 mg/kg) and lamotrigine (20 mg/kg) significantly potentiated their protective effects which were significant as compared to their effect alone.
Systemic picrotoxin (1 mg/kg) pretreatment with sub effective dose of gabapentin (50 mg/kg) or lamotrigine (20 mg/kg) significantly attenuated their protective effect.
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potentiated the effect of sub-effective dose of AEA (0.5 μg/mouse, i.c.v ., AM404 (0.05 μg/mouse, i.c.v) or URB597 (0.01 μg/mouse, i.c.v) in both the paradigms.
On the other hand, clonidine [α2-adrenoceptor agonist] augmented the anticonvulsant effect of a sub-effective combination of lithium (5 mg/kg i.p).
Pretreatment of animals with methylene blue (3.75 mg/kg i.p., an inhibitor of NO synthase and soluble guanylate cyclase — sGC) or (1H-[1,2,4] oxadiazolo[4,3-a]quinoxalin-1-one) (ODQ, 2 mg/kg, i.p., a specific inhibitor of sGC) significantly caused a synergistic effect with a sub-effective dose of tramadol (5 mg/kg, p.o). in the FST.
Etazolate at sub-effective dose produced synergistic antidepressant-like effect with conventional antidepressants in the mouse FST.
For example, SB-269970, administered at a dose not exerting a significant antidepressant effect, enhanced the action of sub-effective doses of antidepressant drugs, including the SSRI citalopram, in the TST and FST in mice [ 23, 24, 28].
produced a synergistic antidepressant-like effect in the FST with a sub-effective dose of morphine (1 mg/kg, s.c).
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