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We are studying signaling pathways that regulate oxidative stress responses and cancer cell growth.
In this review, we discuss common OMIC and modeling approaches for studying signaling, emphasizing the philosophical and practical considerations for effectively merging these two types of approaches to maximize the probability of obtaining reliable and novel insights into signaling biology.
While affinity reagents are valuable tools for monitoring protein phosphorylation and studying signaling events in cells, generating them through immunization of animals with phosphopeptides is expensive, laborious, and time-consuming.
Lewis begins by studying signaling problems.
In this review, we discuss strategies used in our laboratory for studying signaling pathways, including subproteome isolation, proteome mining, and analysis of the phosphoproteome.
The Drosophila mesoderm provides an excellent system for studying signaling networks as Drosophila can be subjected to complex genetic manipulations and multiple signaling pathways are coordinately involved throughout mesoderm differentiation.
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I think about this like a biologist who has studied signaling between cells.
The CUMC team is using the new mouse model to study signaling pathways in the brain that drive anorexic behavior, with the ultimate goal of identifying therapeutic targets.
This investigation may provide a useful alternative to study signaling mechanisms of gene silencing in transgenic cells.
Methodologies used to study signaling and gene regulation in the endocrine/reproductive system are also discussed.
Here we present the methodology to study signaling of soluble versus immobilized VEGF through VEGFR-2.
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