"In order to detect an elevation in risk, one needs to study much larger numbers of people," Shore says, especially given that 40% of all Japanese develop cancer.
In the present study, much larger ranges of possible target locations were tested within a block of trials.
In the whole mtDNA study, much larger sample sizes were employed to increase the sensitivity of the mtDNA assay, but only two restriction enzymes were used and consequently, only a few restriction sites were analyzed.
The mutations we have studied caused much larger changes in IP3 sensitivity (∼30-fold, Table 4).
We studied a much larger nationwide sample focusing exclusively on benzodiazepine prescribing patterns and their association with fatal overdoses.
Although 50 patients is a relatively large sample size for such a study, a much larger study is necessary to really have immediate clinical impact.
Since this study was much larger than previous studies, we were able to examine the impact of migraine with aura, migraine without aura, and past history of migraine.
In the other domains, the number of relevant studies was much larger, and often all studies were relevant.
This study, although much larger than the occupational studies cited above, had much lower ranges of PFOA exposure (mean = 6 7 ng/mL), typical of a general population.
There was no evidence that steam inhalation provided symptomatic benefit, and this study was much larger than the combined studies in the Cochrane review, which showed modest benefit.
