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We illustrate the approach by studying a fedbatch bioreactor.
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In the two case studies presented, the volumetric substrate feed rate into a fedbatch bioreactor in which one biomass grows on one limiting substrate is the control input to be optimized.
A nonlinear model predictive controller was designed and applied to a fedbatch bioprocess.
As an example, we compared the behaviors of two strains inside a fedbatch reactor, growing at 0.1 hr−1 and 0.25 hrespectivelyvely.
In contrast to batch mode, osmotic or toxic effects due to high substrate concentrations can be avoided in a fedbatch culture.
In a fedbatch process producing DHA with C. cohnii (de Swaaf et al. 2003b), the acetic acid used as the carbon/energy substrate was added via a pH control system to maintain a pH of 6.5.
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