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Each medication in this study was dispensed from a vertically-positioned bottle, but the angle of instillation has been found to differentially affect drop size and thus the number of days of therapy achieved [ 12].
At the baseline visit, subjects received study medication sufficient for 4 weeks; at the week 4 visit, medication sufficient for the remaining 4 weeks of the study was dispensed.
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The majority of the injectable therapies in this study are dispensed through pharmacies which were captured using National Drug Code (NDC) claims.
Study medication was dispensed at each study visit following a telephone call to RAMOS to obtain the next blinded treatment pack number for each patient.
Study medication was dispensed into identical bottles and labelled with participant numbers by a staff member not otherwise involved in the study.
Blinded medication provided by the study sponsor was dispensed.
Study drug was dispensed according to the instructions provided via the IVRS.
Study treatment was dispensed by the investigator at the inclusion visit M0.
Study drug was dispensed to subjects following the 4 PM assessment.
The study medication was dispensed in an 8-week supply at 0, 8, and 16 weeks.
On enrolment, each patient was assigned to the next consecutive treatment number and the corresponding study medication was dispensed in an open-label manner.
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