A study was considered to be of 'high quality' if it satisfied at least 50% of the maximum available quality score.
The flux decay in this study was considered to be caused by gradual compression of the membrane which was confirmed by a compression test.
The Dutch study was considered to be of good methodological quality, although it had room for many improvements [30].
The study was considered to be part of routine care, and the need for written informed consent was waived.
The need for individual patient consent was waived by the Research Ethics Committee as the study was considered to be a quality assurance project.
From the rapid elevation of plasma IL-6 throughout the experimental period, the immune activation model in this study was considered to simulate a part of the innate immune response to influenza virus infection.
Also, as the study was considered to be mainly hypothesis-generating and not so much hypothesis-controlling, we believe that findings worthy of further research might be missed by applying too rigid criteria to the statistical analyses.
In this scenario, in each patient in whom an aneurysm was detected which was deemed not suitable for coiling by MRA or CTA, an additional DSA study was considered to be performed.
Our study was considered to be part of routine clinical practice by the appropriate ethics committee (Commission Ethique de la Société de Réanimation de Langue Française, SRLF, Number 14-29), so no informed consent was required from the patients or their relatives.
The enlargement rate in the present study was considered to be less than those in previous reports (Achtnich et al., 2013; Lee et al., 2012; Siebold & Cafaltzis, 2010), because the estimated enlargement rate "in diameter" was 3.0% in the anterior and 18.5% in the posterior tunnels if the tunnel enlargement occurred in posterior and lateral directions equally.
The case presented in the current study was considered to be a borderline Class II case not only because four premolars and all wisdom teeth were extracted but also because of the good facial aesthetics in combination with a skeletal Class II case.
