6 Out of 17 internet smoking cessation RCTs included in Myung et al's 21 meta-analyses, only one study mentioned the rationale of the achieved sample size.
Our study confirms the rationale of these recommendations and identifies the ethnic groups particularly at risk, as well as North African women and Southern Asians of both sexes.
Our study reinforces the rationale of selective pharmacologic inhibition of prostate cancer cell survival using statins and suggests re-purposing of lipophilic statins such as simvastatin for prostate cancer therapy in humans.
Therefore, we recommend that future studies report on the rationale of the achieved sample size.
Molecular docking studies validated the rationale of pharmacophoric design and are in accordance to the in vitro results.
Such studies show the rationale of applying therapy early on.
There are few studies analysing the rationale of the observed sex differences.
Recent epidemiologic studies well support the rationale of the current study, namely to evaluate year of diagnosis (in this case five year period), sex, race, age and Lauren type.
Although better evidence is necessary, the present study also supports the rationale of an important role for androgen depletion, as low-level DHT can promote malignant CRPC cells progression through Wnt/ β-catenin pathway.
