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This newly developed, defined in vitro model was used to study the differentiation of fetal rat skeletal muscle and it promoted the formation of myotubes from the dissociated rat fetal muscle cells.
Some of the researchers at the centre will study the differentiation of stem cells into other cell types, one group by using human embryonic stem cell biology and another by studying early embryo development.
It is also relatively simple to clone and manipulate them in culture; thus offering a convenient model system to study the differentiation plasticity of mammalian cells.
These cells differentiate rapidly, form contractile myotubes, express characteristic marker genes and, therefore, serve as a bona fide in vitro model to study the differentiation of myoblasts to myotubes [25].
Recently, codon usage has also been investigated to study the differentiation of mitochondrial PCGs [ 12].
In this study the differentiation status of the tumors was not examined.
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We studied the differentiation properties of isolated rat embryonic postmigratory CNCCs, expressing p75 neurotrophin receptor (p75NTR).
For this reason we studied the differentiation process leading to in vitro woven bone formation in order to better understand the mechanisms involved as well as bone tissue formation after transplantation in vivo.
In addition, we studied the differentiation state of cells in the EST protocol with time to elucidate the transition of pluripotent ESC to more differentiated cell types.
In some studies, the differentiation between the two constructs has thus not been straightforward but required interpretation.
By using a collection of plant and bacterial mutants inducing non-functional, Fix− nodules, we studied the differentiation processes of the symbiotic partners together with the nodule transcriptome, with the aim of unravelling links between cell differentiation and transcriptome activation.
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