Subsequent Phase II and Phase III studies explored the combination between imatinib and hydroxyurea in the treatment of recurrent glioblastoma, but no clinically meaningful antitumor effect was observed [ 106- 108].
To determine the minimal inhibitory concentrations (MICs) of bacteriocin PsVP-10, chlorhexidine and triclosan on S. mutans and S. sobrinus and to study the potential synergistic combination between these antimicrobial and the bacteriocin PsVP-10.
In this study, results of the combination between U-statistics & Mahalanobis distance algorithms are used to distinguish anomalous values from background on an accurate point of view.
On the basis of these premises, our group started a phase II multicenter study, based on the combination between sorafenib and octreotide LAR (So.LAR protocol) in order to assess its safety and activity in advanced HCC patients.
Moreover, for 120 persons reporting more than one indicator disease, we performed the chi-square test to study the association between different combinations of multiple indicator diseases and late presentation.
Studies have shown that the combination between silane and acidic functional monomers accelerate the hydrolyze reaction of alkoxy groups in silanol, increasing the reactivity of silanes [16 22].
To study the association between appropriateness, timing, and combination of antimicrobial/antibiotic therapy and hospital mortality (dependent variable), forward step-wise logistic regression analyses were performed.
To study the association between PE and possible combinations of the VEGF variants, we performed a haplotype analysis on for the four VEGF SNPs.
In the present study, we have demonstrated that the combination between the standard chemotherapy agent GEM and cannabinoids synergistically inhibited pancreatic adenocarcinoma cell growth by a ROS-dependent autophagic cell death.
The study is carried out by exploiting the combination between a potential flow method, which is used to describe the evolution of the wave system up to the onset of the modulational instability, and a two-fluids Navier Stokes solver which describes the strongly non-linear air water interaction taking place during breaking events.
